Alzheimer’s Drug Free

Now that this new study has also found that people with depression are twice
as likely to develop certain forms of dementia, it highlights the fact that there
could be a common cause, and that could very well be a lack of vitamin D.

Making sure you’re getting enough sunlight exposure to have healthy vitamin
D level is a crucial factor in treating depression or keeping it at bay. One previous study found that people with the lowest vitamin D were
11 times more prone to be depressed than those who had normal levels. Vitamin D deficiency is actually more the norm than the exception and has previously been
been implicated in both psychiatric and neurological disorders. ( for the rest of this story please use this link below:)
http://articles.mercola.com/sites/articles/archive/2010/07/20/does-depression-cause-alzheimers-disease-vitamin-d-helps-both.aspx
https://articles.mercola.com/sites/articles/archive/2018/02/22/link-between-sugar-and-alzheimers.aspx

More promising research on Ashwagandha for Alzheimer’s

The featured study is not the first time this humble herb has been implicated in improved brain health among Alzheimer’s disease patients. In 2005, researchers
found that withanolide derivatives (withanolide A, withanoside IV, and withanoside VI)
isolated from ashwagandha improved neurite extension
in both normal and damaged brain cells in Alzheimer’s disease model mice.³ This is a key component of treating the disease, as researchers pointed out:
http://articles.mercola.com/sites/articles/archive/2012/04/07/ashwaganda-effect-on-alzheimers-disease.aspx
https://www.cancertutor.com/budwig/ 1/3 way down the page.
http://www.greenmedinfo.com/blog/lion-s-mane-mushroom-unparalleled-benefits-your-brain-and-nervous-system/
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https://greenmedinfo.com/blog/b-vitamins-slow-alzheimer-s-brain-atrophy-7-fold
https://greenmedinfo.com/content/sesame-waste-product-beats-alzheimers-drugs-clinical-trial

THIS IS HUGE:
https://jefftbowles.com/vitamin-d3-deficiency-causes-most-human-disease/
https://pubmed.ncbi.nlm.nih.gov/35268010/
https://www.sciencedirect.com/science/article/pii/S2475299123265956 (creatine)
https://link.springer.com/article/10.1007/s40279-023-01870-9 (creatine)

https://www.buckinstitute.org/news/memory-loss-associated-with-alzheimers-reversed-for-first-time/
https://www.drperlmutter.com/yes-alzheimers-can-be-reversed/
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Blueberries for AD:
https://pubmed.ncbi.nlm.nih.gov/35458181/

STORY AT-A-GLANCE

Niacinamide (aka nicotinamide) is a form of niacin (vitamin B3) that plays an important role in energy metabolism. Without it, your mitochondria cannot make energy
Niacinamide is also a precursor to NAD+, which is essential in the conversion of food to energy, maintaining DNA integrity and ensuring proper cell function. NAD+ is also a primary fuel for longevity proteins that become depleted with age
According to recent research, a century-long decline in our basic metabolic rate (BMR) can by itself account for the obesity epidemic. For some reason, we’re spending less energy (burning fewer calories) now, when resting, than people did in decades past
Consumption of polyunsaturated fats may be to blame for this BMR decline. Niacinamide has potent antiobesity effects and also helps inhibit release of inflammatory PUFAs from fat cells
Niacinamide can also help prevent neurodegeneration, kidney disease and heart failure, and reverse leaky gut
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In another May 2023 article,⁷ Dinkov reviews evidence showing niacinamide may help prevent neurodegeneration by allowing for higher energy levels through energy metabolism in the mitochondria. “There are many studies, going back decades, demonstrating that a drop in NAD+ levels, and thus of NAD/NADH, is a common feature of virtually all neurodegenerative diseases,” he writes.

Studies have also demonstrated that raising NAD+ levels can help prevent and treat many neurological conditions, including Alzheimer’s and ischemic stroke. Dinkov goes on to cite a recent study^8,9 that suggests the primary purpose of autophagy, particularly autophagy in your brain, is to maintain optimal NAD+ levels.

When autophagy is low, the resulting NAD depletion causes cytotoxicity in the brain cells and degeneration of brain tissue. Since declining NAD+ levels appear to be what’s behind the neurodegenerative processes, the authors suggest the remedy is to raise NAD+ using precursors such as nicotinamide, nicotinamide mononucleotide (NMN), nicotinamide riboside (NR) or niacin (vitamin B3).

Of these, I’m convinced niacinamide is the best. I’ll review why in the next section. The reason so few promote it is because it’s incredibly inexpensive, so there’s no financial incentive at play.
SOURCE: https://articles.mercola.com/sites/articles/archive/2023/06/22/health-benefits-of-niacinamide.aspx?
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As a blanket recommendation for optimal health, I recommend taking 50 mg of niacinamide three times per day. Niacinamide will only cost you about 25 cents a month if you get it as a powder. Typically, one-sixty-fourth of a teaspoon of niacinamide powder is about 50 mg. You can easily find a set of measuring spoons on Amazon that have a 1/64 teaspoon.

The reason I recommend getting it in powder form is because in most supplement brands, the lowest available dose is 500 mg, and that will decrease NAD+ due to negative feedback on NAMPT, which is the opposite of what you’re looking for.

Also, please note that although niacinamide and niacin are both called vitamin B3, niacin will not activate NAMPT like niacinamide, so it is best to use niacinamide. Additionally, niacinamide, unlike niacin, will not cause flushing which is due to a large release of histamine.
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https://pubmed.ncbi.nlm.nih.gov › 37271037

Nicotinamide mononucleotide improves the Alzheimer’s disease by …

Nicotinamide mononucleotide improves the Alzheimer’s disease by regulating intestinal microbiota Biochem Biophys Res Commun. 2023 May 29;670:27-35. doi: 10.1016/j.bbrc.2023.05.075. Online ahead of print. Authors Xiaodong Zhao 1 , Mengmeng Kong 2 , Yilin Wang 3 , Yingxin Mao 4 , Huilian Xu 5 ,

https://www.ncbi.nlm.nih.gov › pmc › articles › PMC8002905
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Min mark 9:20-10:45

Glycine and N‐acetylcysteine (GlyNAC) supplementation in older adults …

Aging is the greatest risk factor for cognitive decline and dementia affecting millions of OA and results in impaired learning, memory, executive function, attention, language, perceptual motor function, and social cognition, 59, 60 but effective interventions are either limited or lacking. Glucose is the primary fuel for the brain.

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Vitamin E:
conclusions:

The number of people affected by AD is continuously increasing and, for this reason, a treatment able to prevent or delay the progression of the disease is needed. Evidence showed that oxidative stress plays a main role in AD pathology. In particular, it was observed that Aβ takes part in increasing oxidative stress, causing ROS production and leading to lipid peroxidation and protein oxidation. In turn, oxidative stress promotes Aβ production. Given this, antioxidant compounds may be helpful in the prevention/treatment of AD. Vitamin E is one of the most important antioxidant and some data indicated that it could counteract Aβ-induced oxidative stress. Evidence from preclinical studies showed that vitamin E administration may be beneficial in AD. Indeed, vitamin E is not only able to reduce Aβ-induced oxidative stress, but also able to improve memory and cognitive deficits. In particular, the precocious and prolonged administration seemed to be related to better results. Even if α-tocopherol is the most investigated member of vitamin E family, also tocotrienols showed good results in AD animal models, exerting in some cases a stronger action than α-tocopherol. Furthermore, the combination of vitamin E with other compounds with anti-inflammatory or antioxidant activity, that act synergistically, may be useful for the treatment of AD. However, clinical trials provided conflicting results about vitamin E efficacy in the prevention and/or treatment of AD. High vitamin E doses and prolonged supplementation seem to be associated with better results. Moreover, a higher intake of foods rich in vitamin E, which contain a combination of different forms of vitamin E, was associated with a better cognitive function. However, further studies are required to obtain clear results about vitamin E efficacy in AD. In this context, trials evaluating different doses and forms of vitamin E and their combination could be helpful.
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751107/

FUNGUS & ALS:
https://www.alzheimers.net/1-18-16-fungus-cause-alzheimers https://pubmed.ncbi.nlm.nih.gov/24614898/
https://annshippymd.com/surprising-link-fungus-alzheimers-disease/
https://nutritionreview.org/2015/10/does-fungus-cause-alzheimers-disease/
https://www.sciencedaily.com/releases/2020/08/200831131633.htm
http://web.archive.org/web/20150319140708/http://www.cancertutor.com/alzheimers/
http://www.natural-treatment.info/msm6.htm

UCLA STUDY: treating Alzheimer’s naturally drug-free
https://www.sciencealert.com/small-trial-shows-memory-loss-from-alzheimer-s-disease-can-be-reversed
http://newsroom.ucla.edu/releases/memory-loss-associated-with-alzheimers-reversed-for-first-time
https://www.ncbi.nlm.nih.gov/pubmed/25997382
https://www.drperlmutter.com/alzheimers-drugs-worsen-cognitive-function/
https://www.ncbi.nlm.nih.gov/pubmed/25642988
https://blogs.webmd.com/webmd-guests/2014/02/dementia-is-gluten-to-blame.html
http://www.greenmedinfo.com/blog/mct-fats-found-coconut-oil-boost-brain-function-only-one-dose
https://bebrainfit.com/coconut-oil-dementia/
NIR infrared light therapy:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568598/?fbclid=IwAR09vkFk9tjGgDLDqmfM5pj1tsDgSoKBuGRAu5UfrbGAD2jq6jm2Fs6BYcY
https://wellnessjim.com/2017/04/06/nir-infrared-light/
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Lyme misdiagnosed as Alzheimer’s:
https://www.cbsnews.com/news/kris-kristofferson-misdiagnosed-alzheimers-has-lyme-disease/?fbclid=IwAR1D_3DhQiS_XCIXLt7DRDaXVBO-ZUcMwNbKrSgajlZxNULwJp8vvBvHUS8